منابع مشابه
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitotic histone H3 phosphorylation, and caused aberrant mitotic phenotypes. It was subsequently established that these compounds were in fact potent inhibitors of aurora A and B kina...
متن کاملExistence of dynamic tautomerism and divalent N(I) character in N-(pyridin-2-yl)thiazol-2-amine
N-(pyridin-2-yl)thiazol-2-amine is a versatile chemical functional unit present in many therapeutically important species. Quantum chemical analysis shows that there are six competitive isomeric structures possible for this class of compounds within a relative energy difference of ∼4 kcal/mol. Some of the isomeric structures possess divalent N(I) character. There appears to be a competition bet...
متن کاملSupporting Information Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin- 2-amine Aurora Kinase Inhibitors
Supporting Figure 1. Kinase inhibitory activity of compound 18 . S2 Supporting Figure 2. Activity of compound 18 in tumor models S3 Synthesis and Characterization of Compounds 7h, 11–17, and 19–24 S4 Biopharmaceutical Profiling S7 Rat Pharmacokinetics S7 Cell Viability Assay S7 Murine P388/D1 Leukemia Model S7 NCI-H460 Xenograft S7 X-Ray Crystallography S8 Molecular Modeling S8 Supplementary Re...
متن کاملN-Benzylpyridin-2-amine
In the crystal of the title compound, C(12)H(12)N(2), inter-molecular N-H⋯N hydrogen bonds form rings of graph-set motif R(2) (2)(8) and C-H⋯π inter-actions further consolidate the dimers. Neighbouring dimers are further connected into a three-dimensional network by C-H⋯π inter-actions. The benzyl and pyridyl rings form a dihedral angle of 67.2 (1)°
متن کاملN-(2-aminobenzyl)-N,N-bis(quinolin-2-ylmethyl)amine.
The title new diquinaldine derivative, C27H24N4, forms molecular assemblies organized by intermolecular quinoline pi-pi stacking [3.356 (3) and 3.440 (3) A] and both inter- and intramolecular N-H...N hydrogen bonds [3.039 (3)-3.104 (3) A and 129 (2)-172 (2) degrees]. The combination of such interactions provides readily definable contacts that propagate along each crystallographic axis.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2012
ISSN: 1600-5368
DOI: 10.1107/s1600536812035301